ANASTOSEAL: “Seal and strengthen intestinal anastomosis in colorectal cancer surgery”: Prospective observational study.
The anastomotic leak prevention can bring benefits to the patient and the health system. An effective prevention is based on the knowledge of the repair mechanisms that lead to the consolidation of intestinal anastomosis.
The use of intraoperative procedures to prevent dehiscence of the anastomosis, such as the addition of additional manual points, the mechanical suture and / or patches of collagen (reinforcement so called also buttressing) or sealants (fibrin or cyanoacrylate glues, such as Glubran® 2) is the rationale that led to the design of this study. Although today we have technologically advanced mechanical staplers, it is crucial to prevent anastomotic dehiscence. At the moment experimental results show that Glubran® 2 is a suitable potential “reinforcement” of intestinal anastomoses both manual and linear intracorporeal. Glubran 2 applied after the packaging of the mechanical anastomosis, polymerizes in a short time closing the micro spaces of the suture line between one point and the other, expressing an adhesive, hemostatic and sealant action on the tissues, creating an effective antiseptic barrier against the most common infectious agents or pathogens.
The aim of the study is to evaluate the incidence of anastomotic fistula after application of reinforcement with the modified cyanoacrylate sealant, within the first 10 postoperative days and compare the results with historical literature data in patients in whom the sealing reinforcement application was not used.